VESIsorb

Overview

VESIsorb is an advanced drug delivery system designed to dramatically improve the bioavailability of poorly absorbed ingredients, particularly in nutraceuticals and pharmaceuticals. It is a proprietary colloidal droplet delivery technology that enhances the absorption and plasma concentration of active compounds such as coenzyme Q10, omega-3 fatty acids, curcumin, resveratrol, vitamin K2, vitamin D3, cannabinoids, and many others. Developed over the past 30 years, VESIsorb has been validated through well-designed pharmacokinetic studies and peer-reviewed publications, establishing it as a leading platform for improving oral absorption of lipophilic and difficult-to-absorb substances. This technology is widely used by medical and healthcare brands globally, spanning applications in supplements, cosmetics, and medical devices.¹

Forms and Variations

VESIsorb is not a supplement itself but a delivery system incorporated into various formulations to enhance bioavailability. It is commonly used in softgel capsules containing active ingredients such as hemp-derived CBD, coenzyme Q10 (including QH ubiquinol), omega-3 EFAs, curcumin, vitamin D, and other lipophilic compounds. The system forms self-assembling colloidal droplets upon ingestion, facilitating rapid dissolution in aqueous environments and improved absorption. Variations include formulations tailored for cannabinoids and terpenes, as well as other nutraceuticals. The choice of VESIsorb-based products is often driven by the need for faster onset, higher plasma levels, and improved overall efficacy compared to standard oil or powder formulations.²³

Dosage and Administration

Dosage depends on the active ingredient delivered via the VESIsorb system rather than the delivery system itself. For example, in the Hemp CBD VESIsorb formulation, a typical dose is one softgel capsule daily containing 25 mg of CBD. It can be taken with or between meals as directed by a healthcare professional. The VESIsorb system enhances absorption regardless of food intake, but following manufacturer or professional guidance is recommended. Because VESIsorb improves bioavailability, lower doses of active ingredients may achieve therapeutic effects compared to conventional formulations, but specific dosing should be based on the ingredient and clinical context.²

Scientific Research and Mechanism of Action

VESIsorb technology is based on a self-emulsifying drug delivery system (SEDDS) that forms nano-sized colloidal droplets (approximately 40-50 nm) upon contact with aqueous fluids in the gastrointestinal tract. This increases the surface area and solubility of lipophilic compounds, facilitating faster and more efficient absorption into the bloodstream. Clinical pharmacokinetic studies have demonstrated that VESIsorb formulations significantly increase peak plasma concentrations (Cmax) and area under the curve (AUC) compared to standard formulations. For instance, a randomized, double-blind crossover trial showed that 25 mg of CBD delivered via VESIsorb achieved a 4.4-fold higher Cmax and 2.85-fold higher AUC within 8 hours compared to a standard MCT oil formulation, with peak absorption occurring in 1 hour versus 3 hours.²⁴ This enhanced bioavailability is attributed to the formation of stable, uniform nanoemulsions that improve dissolution and intestinal uptake. The technology has been validated across multiple ingredients, including cannabinoids, coenzyme Q10, omega-3s, and fat-soluble vitamins, making it a versatile platform for improving oral delivery of challenging compounds.¹³

Benefits and Potential Uses

VESIsorb"s primary benefit is its ability to dramatically enhance the bioavailability of poorly absorbed, lipophilic ingredients, leading to faster onset of action and higher systemic exposure. This can translate into improved efficacy and potentially lower required doses of active compounds. It is widely used for ingredients such as:

• Hemp-derived cannabinoids (CBD): Faster absorption and higher plasma levels support better therapeutic effects in pain, inflammation, and anxiety management.
• Coenzyme Q10 and ubiquinol: Enhanced delivery supports cardiovascular health and mitochondrial function.
• Omega-3 fatty acids: Improved absorption aids in cardiovascular, cognitive, and inflammatory health.
• Curcumin and resveratrol: Increased bioavailability enhances antioxidant and anti-inflammatory benefits.
• Fat-soluble vitamins (D3, K2, A): Better absorption supports bone, immune, and overall health.

By overcoming the common challenge of poor oral absorption, VESIsorb enables more effective supplementation and pharmaceutical formulations, expanding potential clinical and wellness applications.¹²

Side Effects and Risks

VESIsorb itself is a delivery technology composed of food-grade emulsifiers, vegetable oils, and fatty acids, generally recognized as safe and well tolerated. Side effects are typically related to the active ingredient delivered rather than the delivery system. For example, CBD formulations using VESIsorb have shown good tolerability in clinical studies with no significant adverse effects attributed to the delivery system. However, individuals sensitive to emulsifiers or specific excipients should exercise caution. As with any supplement or pharmaceutical, allergic reactions or gastrointestinal discomfort are possible but uncommon. There are no known unique risks or contraindications specifically linked to the VESIsorb delivery system.⁴

Interactions and Precautions

Since VESIsorb enhances the bioavailability of active compounds, it may increase the systemic exposure and effects of these ingredients, which could alter interactions with medications. For example, higher CBD plasma levels might potentiate interactions with drugs metabolized by cytochrome P450 enzymes. Therefore, individuals on medications should consult healthcare providers before using VESIsorb-based products. Pregnant or breastfeeding women, children under 18, and people with specific health conditions should use caution and seek professional advice. There are no specific medical procedure considerations unique to VESIsorb, but standard precautions for the active ingredients apply.²⁴

Impact on Biomarkers

By improving absorption, VESIsorb formulations can lead to higher plasma concentrations of active ingredients, which may influence relevant biomarkers. For example, enhanced CBD bioavailability can affect inflammatory markers, oxidative stress parameters, and liver enzyme levels. Similarly, improved delivery of coenzyme Q10 or omega-3 fatty acids may positively impact cardiovascular biomarkers such as lipid profiles and antioxidant status. The delivery system itself does not directly alter biomarkers but modulates the pharmacokinetics of the active compounds, potentially enhancing their measurable biological effects.²⁴

Overdose and Toxicity

VESIsorb is a delivery system and does not have intrinsic toxicity; however, its ability to increase bioavailability means that overdosing on the active ingredient it delivers could lead to toxicity. For example, excessive intake of CBD or fat-soluble vitamins via VESIsorb formulations could increase the risk of side effects or toxicity associated with those compounds. Users should adhere to recommended dosages for the active ingredients and consult healthcare professionals to avoid overdose. The system’s enhanced absorption underscores the importance of careful dosing and monitoring.²

Disclaimer

The information provided in this document is for educational purposes only and does not constitute medical advice. It is essential to consult with a qualified healthcare professional for any health concerns or before making any decisions related to your health or treatment.