Turkesterone (Ajuga turkestanica Extract)

Overview

Turkesterone is a naturally occurring phytoecdysteroid, a type of plant steroid found primarily in the herb Ajuga turkestanica, native to Central Asia. It is classified as a plant-based anabolic compound known for its muscle-building and adaptogenic properties. Traditionally, Ajuga turkestanica has been used in folk medicine for its potential health benefits, including muscle support and skin hydration. Turkesterone gained attention as a supplement for enhancing muscle growth, endurance, and recovery without the hormonal side effects associated with anabolic steroids, as it does not bind to androgen receptors.¹⁴

Forms and Variations

Turkesterone supplements are commonly available as standardized extracts of Ajuga turkestanica, often standardized to contain around 10% turkesterone content. These extracts may come in capsule or powder form. Some products use whole herb extracts, while others isolate turkesterone or combine it with other phytoecdysteroids like 20-hydroxyecdysone. The choice of form depends on desired potency, bioavailability, and intended use. Standardized extracts ensure consistent turkesterone levels, which is important for efficacy. Some formulations also include complementary ingredients to support muscle recovery and endurance.²¹

Dosage and Administration

Typical dosages of turkesterone supplements range from 250 mg to 500 mg per day, often divided into two doses. It is usually taken orally with meals to enhance absorption. Frequency is commonly once or twice daily depending on the product and user goals. Long-term use is considered safe when taken as directed, with no need for post-cycle therapy since turkesterone does not disrupt natural hormone balance. Users are advised to follow manufacturer guidelines and consult healthcare providers if combining with other supplements or medications.⁴²

Scientific Research and Mechanism of Action

Scientific studies indicate that turkesterone promotes muscle growth primarily by enhancing protein synthesis and supporting muscle cell repair. Unlike anabolic steroids, turkesterone does not bind to androgen receptors but activates alternative anabolic pathways, possibly involving increased mRNA translation and improved cellular energy metabolism. Research also suggests it reduces muscle fatigue by boosting ATP production and lowering cortisol levels, which helps prevent muscle degradation. Additionally, Ajuga turkestanica extracts have been shown to improve skin hydration by regulating epidermal water transport through aquaporin channels, indicating broader bioactivity beyond muscle effects. While human clinical trials are limited, in vitro and animal studies support its anabolic and adaptogenic potential.²³⁴

Benefits and Potential Uses

Turkesterone is primarily used to support lean muscle growth, enhance strength, and improve exercise recovery. It may reduce inflammation and lactic acid buildup, facilitating faster muscle repair and endurance. Its adaptogenic properties suggest benefits in reducing physical and mental fatigue. Some traditional uses of Ajuga turkestanica include cardiovascular protection and maintenance of aged skeletal muscle. Additionally, its skin hydration effects may offer anti-aging benefits. Turkesterone is considered a safer alternative to anabolic steroids due to its non-androgenic nature, making it attractive for athletes and fitness enthusiasts seeking performance enhancement without hormonal side effects.²⁴⁵

Side Effects and Risks

Turkesterone is generally well tolerated with minimal reported side effects. Because it does not interact with androgen receptors, it avoids common steroid-related adverse effects such as hormonal imbalances, gynecomastia, or hair loss. Some users may experience mild gastrointestinal discomfort or fatigue if taken in excessive doses. However, long-term safety data in humans is limited, so caution is advised. Individuals with allergies to plants in the Lamiaceae family or those with underlying health conditions should consult a healthcare professional before use.²⁴

Interactions and Precautions

There are no well-documented interactions between turkesterone and medications, but due to limited research, caution is recommended when combining it with hormone therapies or immunosuppressants. Pregnant or breastfeeding women, children, and individuals with hormone-sensitive conditions should avoid use or seek medical advice. Because turkesterone may influence protein metabolism and cortisol levels, those undergoing medical procedures or with endocrine disorders should consult healthcare providers before supplementation.⁴

Impact on Biomarkers

Turkesterone supplementation may influence biomarkers related to muscle metabolism, such as increased protein synthesis markers and reduced cortisol levels, reflecting improved recovery and reduced stress. It does not appear to affect androgen hormone levels or liver enzymes significantly, distinguishing it from anabolic steroids. However, comprehensive biomarker studies in humans are limited.²⁴

Overdose and Toxicity

There is no established toxicity profile for turkesterone, but excessive intake beyond recommended doses may cause mild gastrointestinal upset or fatigue. No serious toxic effects have been reported in available studies. Safe upper limits have not been definitively established, so adherence to manufacturer dosing guidelines is important. Due to its natural origin and non-androgenic mechanism, turkesterone is considered low risk for overdose toxicity.²⁴

Disclaimer

The information provided in this document is for educational purposes only and does not constitute medical advice. It is essential to consult with a qualified healthcare professional for any health concerns or before making any decisions related to your health or treatment.