Gamma Oryzanol
About Gamma Oryzanol
Gamma Oryzanol
Overview
Gamma oryzanol is a mixture of ferulic acid esters of phytosterols and triterpene alcohols, primarily derived from rice bran oil. It was first isolated in the 1950s and has been used in various applications, including as a food additive, pharmaceutical material, and in the cosmetic industry[1]. Traditionally, it has been used in Japan for managing menopausal symptoms, anxiety, and high cholesterol[2]. Gamma oryzanol is recognized for its antioxidant and anti-hyperlipidemic properties, making it a valuable compound in both nutrition and medicine[3].
Forms and Variations
Gamma oryzanol is typically available in powder or crystalline form and is often used as a dietary supplement. It can be found in various formulations, including capsules and tablets, designed to enhance bioavailability and absorption. The choice of form may depend on individual preferences or specific health needs, such as cholesterol management or antioxidant supplementation[1].
Dosage and Administration
The commonly recommended dosage of gamma oryzanol is around 500 mg per day, though some studies suggest doses as low as 300 mg for cholesterol management[5]. It is generally advised to take the supplement with meals to enhance absorption and minimize potential gastrointestinal side effects. Best practices include consulting with a healthcare provider before starting any new supplement regimen[1].
Scientific Research and Mechanism of Action
Gamma oryzanol has been studied for its potential to reduce cholesterol levels by inhibiting intestinal cholesterol absorption[5]. Its antioxidant properties, primarily attributed to ferulic acid, contribute to its anti-inflammatory and anticarcinogenic effects[1]. While some research suggests benefits for menopause symptoms and athletic performance, these uses are less well-supported by clinical evidence[5]. The current state of research highlights gamma oryzanol"s potential in managing hyperlipidemia and its role as a multifunctional excipient in drug formulations[3].
Benefits and Potential Uses
Gamma oryzanol is primarily used for its anti-hyperlipidemic effects, helping to manage high cholesterol and triglyceride levels[5]. It also exhibits antioxidant properties, which may contribute to its potential benefits in reducing inflammation and protecting against certain diseases[1]. Additionally, gamma oryzanol is used in the cosmetic industry for its skin-protective effects[2]. Potential uses include improving menopausal symptoms and enhancing athletic performance, though more research is needed to confirm these benefits[5].
Side Effects and Risks
Gamma oryzanol is generally considered safe for most adults when taken orally or applied topically[5]. However, high doses may cause side effects such as dry mouth, sleepiness, hot flushes, irritability, and lightheadedness in some individuals[1]. It is crucial to consult with a healthcare provider before use, especially for pregnant or breastfeeding women, as there is limited information on its safety in these populations[5].
Interactions and Precautions
There is limited information on specific interactions between gamma oryzanol and medications. However, individuals with thyroid issues should exercise caution, as gamma oryzanol may affect thyroid function[5]. Pregnant or breastfeeding women should avoid its use due to insufficient safety data[5]. Additionally, individuals undergoing medical procedures should consult with their healthcare provider before starting any new supplements[5].
Impact on Biomarkers
Gamma oryzanol may influence cholesterol levels by reducing LDL cholesterol and triglycerides, potentially impacting lipid profiles in blood tests[5]. Its antioxidant properties may also affect markers of oxidative stress, though specific effects on other biomarkers are less well-documented[1].
Overdose and Toxicity
While gamma oryzanol is generally safe, excessive intake may lead to adverse effects such as those mentioned earlier (dry mouth, sleepiness, etc.)[1]. There is no established safe upper limit for gamma oryzanol, but doses above 600 mg per day are not commonly recommended[1]. Symptoms of toxicity are not well-documented, but caution should be exercised to avoid potential adverse effects[1].
Disclaimer
The information provided in this document is for educational purposes only and does not constitute medical advice. It is essential to consult with a qualified healthcare professional for any health concerns or before making any decisions related to your health or treatment.
Products
| Name | Brand | Serving Size | Ingredients |
|---|---|---|---|
| Gamma Oryzanol Power | Optimum Nutrition | 1.00 capsule | |
| Rice Bran Antioxidant | Nature's Bounty | 1.00 tablet | |
| Performance Plus | MusclePharm | 1.00 Serving | |
| Pure Gamma Oryzanol | Swanson Health Products | 1.00 veg capsule | |
| Athlete's Edge | GNC | 1.00 tablet |
Supplement Interactions
Recommended to Take With
Gamma oryzanol, a lipid-soluble antioxidant, may synergize with phospholipids to enhance membrane protection and antioxidant effects when taken together.
Confidence: Moderate evidence from antioxidant synergy studies.Gamma oryzanol is a lipid-soluble compound extracted from rice bran oil; its absorption is enhanced by co-ingestion with dietary fats such as vegetable oil.
Confidence: Moderate confidence based on mechanistic plausibility and limited clinical data.Requires Separate Timing
Calcium can interfere with the absorption of various lipophilic compounds and nutrients by forming insoluble complexes or altering gastrointestinal pH. Although direct studies on Gamma Oryzanol absorption are limited, its lipophilic nature suggests potential reduced bioavailability when taken simultaneously with high doses of calcium. Separating intake by at least 2 hours may optimize absorption.
Confidence: Moderate; based on known calcium interactions with fat-soluble nutrients and lipophilic compoundsIron can interfere with absorption of various nutrients through competition and formation of insoluble complexes. While no direct studies on Gamma Oryzanol exist, separating iron and Gamma Oryzanol by 2 hours is prudent to minimize potential absorption issues.
Confidence: Low; inferred from general mineral absorption competitionMagnesium may reduce absorption of some lipophilic compounds by competing for intestinal transport or altering gut motility. No direct evidence exists for Gamma Oryzanol, but cautious timing separation of at least 2 hours is advised to avoid potential absorption interference.
Confidence: Low; theoretical based on mineral competition and limited direct dataTake With And Separate Timing
Both Gamma Oryzanol and Astaxanthin are lipophilic antioxidants that may provide synergistic antioxidant effects. However, simultaneous high doses may compete for absorption via similar fat-dependent pathways. Taking together with a meal rich in fats enhances absorption, but separating doses by a few hours may optimize individual bioavailability.
Confidence: Low; theoretical synergy with limited direct evidenceGamma Oryzanol may provide complementary antioxidant and lipid metabolism support but could compete for absorption pathways; spacing by 1-2 hours may optimize benefits.
Confidence: Limited clinical data; theoretical basis from absorption competition.All Time Users
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