Folate (as Quatrefolic)

Overview

Quatrefolic is a fourth-generation, bioactive form of folate, specifically the glucosamine salt of (6S)-5-methyltetrahydrofolate (5-MTHF), which is the naturally active form of folate the body can use directly without conversion. Unlike synthetic folic acid, which requires enzymatic conversion in the liver to become biologically active, Quatrefolic bypasses this process, making it immediately available for cellular functions. Folate is a vital B-vitamin (B9) essential for DNA synthesis, cell division, red blood cell production, and homocysteine metabolism. It is especially important during periods of rapid growth such as pregnancy, where it supports fetal development and reduces the risk of neural tube defects. Traditionally, folate has been used to prevent anemia and support overall cellular health, but Quatrefolic represents an innovative advancement by offering improved bioavailability and stability compared to older folate forms¹²⁴.

Forms and Variations

Quatrefolic is available primarily as levomefolate glucosamine, a stable, water-soluble, and highly bioavailable form of 5-MTHF. This form is considered a \"finished\" folate, meaning it does not require metabolic activation. It is commonly formulated in capsules and tablets for dietary supplementation. Compared to folic acid and other reduced folate forms like folinic acid, Quatrefolic offers superior stability, solubility, and absorption. These properties make it preferable for individuals with genetic variations in the MTHFR enzyme, which impair the conversion of folic acid to active folate. Manufacturers choose Quatrefolic for its ease of handling, room temperature stability, and enhanced bioavailability, making it suitable for a wide range of health supplements targeting reproductive health, cardiovascular support, mood, and beauty¹⁵.

Dosage and Administration

Typical dosages of Quatrefolic vary depending on the intended use but commonly range from 200 to 400 micrograms daily, aligning with general folate supplementation guidelines. It is often taken once daily with or without food, though some formulations may recommend splitting doses. Because Quatrefolic is already in the active form, it can be taken at any time of day without concern for enzymatic conversion. For pregnant women or those planning pregnancy, supplementation is critical to meet increased folate demands. Best practices include consistent daily intake and consultation with healthcare providers to tailor dosage based on individual needs, especially in cases of genetic polymorphisms affecting folate metabolism²⁴.

Scientific Research and Mechanism of Action

Scientific studies highlight that Quatrefolic, as 5-MTHF glucosamine salt, directly supplies the body with the active folate form, bypassing the need for conversion by the methylenetetrahydrofolate reductase (MTHFR) enzyme. This is significant because many individuals carry MTHFR polymorphisms (notably C677T and A1298C mutations) that reduce enzyme activity, impairing folic acid metabolism and potentially increasing risks for cardiovascular disease, pregnancy complications, and mood disorders. By providing 5-MTHF directly, Quatrefolic supports DNA synthesis, methylation reactions, and homocysteine metabolism more efficiently. Research also shows improved bioavailability and stability compared to calcium salt forms of 5-MTHF, making it a superior choice for supplementation. Current research continues to explore its benefits in reproductive health, cardiovascular protection, and neurological function, confirming its role as a critical nutrient for mitotically active tissues and overall cellular health¹³⁴.

Benefits and Potential Uses

Quatrefolic supplementation offers several proven benefits, including reducing the risk of neural tube defects during pregnancy by ensuring adequate folate levels. It supports red blood cell formation, preventing folate-deficiency anemia. Due to its role in DNA synthesis and cell division, it promotes healthy skin regeneration, hair vitality, and nail health, contributing to beauty and wellness. Additionally, Quatrefolic helps maintain cardiovascular health by lowering homocysteine levels, a risk factor for heart disease. It may also support mood and cognitive function through its involvement in methylation pathways. Potential uses extend to fertility support, immune wellness, and metabolic health. Its ability to bypass MTHFR enzyme deficiencies makes it particularly valuable for individuals with genetic polymorphisms affecting folate metabolism¹²⁴.

Side Effects and Risks

Quatrefolic is generally well tolerated with a low incidence of side effects when taken at recommended dosages. Some individuals may experience mild gastrointestinal discomfort such as bloating or nausea. Because it is a bioactive form of folate, excessive intake could theoretically mask vitamin B12 deficiency symptoms, so caution is advised in individuals with undiagnosed B12 deficiency. People with allergies to glucosamine or related compounds should exercise caution. There are no significant known risks for the general population, but pregnant or breastfeeding women should consult healthcare providers before use. Overall, Quatrefolic"s safety profile is favorable compared to synthetic folic acid¹².

Interactions and Precautions

Quatrefolic may interact with certain medications such as anticonvulsants, methotrexate, and sulfasalazine, which can affect folate metabolism or efficacy. Individuals on these medications should consult healthcare professionals before supplementation. Caution is also advised for people with cancer or those undergoing chemotherapy, as folate can influence cell proliferation. Pregnant and breastfeeding women should use Quatrefolic under medical supervision. Additionally, because Quatrefolic affects homocysteine metabolism, it may influence blood clotting and cardiovascular medications. No specific medical procedure contraindications are noted, but disclosure to healthcare providers is recommended to avoid interactions²⁴.

Impact on Biomarkers

Supplementation with Quatrefolic increases serum and red blood cell folate levels more effectively than folic acid, reflecting improved bioavailability. It also lowers plasma homocysteine concentrations, a biomarker linked to cardiovascular risk. Folate status biomarkers improve, supporting DNA synthesis and methylation processes. These changes can be monitored through blood tests assessing folate and homocysteine levels, providing objective measures of supplementation efficacy²⁴.

Overdose and Toxicity

Overdose of Quatrefolic is rare but excessive intake of folate in general can mask symptoms of vitamin B12 deficiency, potentially leading to neurological damage if untreated. Symptoms of folate toxicity may include gastrointestinal upset, sleep disturbances, and skin reactions. The established upper intake level for folate from supplements is 1,000 micrograms daily for adults. Staying within recommended dosages minimizes risk. Because Quatrefolic is a bioactive form, careful dosing is important, especially in populations with underlying health conditions or those taking medications affecting folate metabolism¹².

Disclaimer

The information provided in this document is for educational purposes only and does not constitute medical advice. It is essential to consult with a qualified healthcare professional for any health concerns or before making any decisions related to your health or treatment.