EPA (Omega-3)
About EPA (Omega-3)
Docosahexaenoic Acid (DHA)
Overview
Docosahexaenoic acid (DHA) is a long-chain omega-3 fatty acid that plays a crucial role in the development and functioning of the human body, particularly in the brain and eyes[1][2]. It is primarily found in fish oil and is known for its anti-inflammatory, neuroprotective, and cardiovascular benefits[2]. Historically, DHA has been part of traditional diets rich in fish, such as the Mediterranean diet, which is associated with healthier hearts[1].
Forms and Variations
DHA supplements are available in various forms, including fish oil capsules, algal oil (for vegetarians and vegans), and fortified foods like infant formula[4]. The choice of form often depends on dietary preferences and the need for vegetarian or vegan options. Algal oil is a popular alternative for those who do not consume fish products[4].
Dosage and Administration
The recommended daily intake of DHA varies, but general guidelines suggest 200–500 mg combined with eicosapentaenoic acid (EPA) for overall health[3]. DHA supplements are typically taken once or twice daily with meals to enhance absorption and reduce gastrointestinal side effects[4].
Scientific Research and Mechanism of Action
DHA works by incorporating into cell membranes, influencing membrane fluidity, and interacting with cell signaling pathways to exert its anti-inflammatory effects[2]. It reduces inflammation by decreasing pro-inflammatory cytokines and inhibiting the NF-κB signaling pathway[2]. Research highlights DHA"s role in improving heart health, cognitive function, and eye health[1][3].
Benefits and Potential Uses
DHA has been linked to several health benefits, including reducing the risk of heart disease, improving ADHD symptoms, and supporting fetal brain development during pregnancy[1][3]. It may also help reduce inflammation in conditions like rheumatoid arthritis and potentially lower the risk of certain cancers[3].
Side Effects and Risks
Common side effects of DHA supplements include gastrointestinal issues such as bloating and fishy aftertaste[4]. While generally safe, high doses may increase the risk of bleeding due to its anticoagulant effects[4].
Interactions and Precautions
DHA may interact with anticoagulant medications, increasing the risk of bleeding[4]. Pregnant women and individuals with bleeding disorders should consult a healthcare provider before taking DHA supplements[4].
Impact on Biomarkers
DHA supplementation can increase the omega-3 index in blood, a marker associated with reduced heart disease risk[3]. It may also improve cholesterol profiles by decreasing triglycerides and increasing HDL cholesterol[3].
Overdose and Toxicity
While DHA is generally safe, excessive intake may lead to gastrointestinal side effects and increased bleeding risk[4]. The safe upper limit for DHA intake is not well-defined, but doses above 3 grams per day are typically not recommended without medical supervision[4].
References
Disclaimer
The information provided in this document is for educational purposes only and does not constitute medical advice. It is essential to consult with a qualified healthcare professional for any health concerns or before making any decisions related to your health or treatment.
Products
Name | Brand | Serving Size | Ingredients |
---|---|---|---|
Ultimate Omega | Nordic Naturals | 2.00 Capsule/Tablet | |
Omega Match Ahiflower Oil Supplement | Purina | 30.00 ml | |
Algae DHA | Corbion | 1.00 capsule | |
DHEA 25mg Capsules | Ortho Molecular Products | 1.00 capsule | |
DHEA Supplement 25mg | BrainMD | 1.00 capsule | |
Pure EPO | Pure Encapsulations | 1.00 capsule | |
Organic Flaxseed Oil Capsules | NOW Foods | 1.00 capsule | |
EyePro | Bausch + Lomb | 1.00 capsule | |
Superba Krill Oil | Aker BioMarine | 1.00 capsule | |
Antarctic Krill Oil | Transparent Labs | 1.00 capsule | |
Krill-plex | Pure Encapsulations | 1.00 capsule | |
SuperiorRed Krill Oil | NatureMyst | 1.00 capsule | |
Omega Balance | Garden of Life | 1.00 capsule | |
Vegan Omega Complex | Vega | 1.00 capsule | |
EicosaCaps Omega 3 & 6 S | Dechra | 1.00 capsule | |
Omega Balance | Therascience | 1.00 capsule | |
EPO Plus | GNC | 2.00 capsules | |
Plant-Based Omega-3 | Vegan Essentials | 2.00 capsules | |
Plant-Based Omega 3-6-9 | MegaFood | 2.00 capsules | |
DHA Brain Support | Nordic Naturals | 1.00 softgel | |
HeartGuard with Aged Garlic and Omega-3 | GNC | 1.00 softgel | |
Aloe Vera & Omega-3 Skin Support | Solgar | 1.00 softgel | |
Astaxanthin Plus Omega-3 | Pure Encapsulations | 1.00 softgel | |
Coconut Oil and Omega-3 Blend | Optimum Nutrition | 1.00 softgel | |
CoQ10 Plus Omega-3 | Garden of Life | 1.00 softgel | |
DHA Omega-3 | KD Nutra | 1.00 softgel | |
DHA Focus | Nature's Bounty | 1.00 softgel | |
Evening Primrose Oil Softgels | Nature's Bounty | 1.00 softgel | |
Omega-3 Flaxseed Oil | GNC | 1.00 softgel | |
Flaxseed Oil with Lignans | Barlean's | 1.00 softgel | |
Vegan Omega-3 Blend | Nature's Bounty | 1.00 softgel | |
Heart Health Formula | Optimum Nutrition | 1.00 softgel | |
Omega Balance | NOW Foods | 1.00 softgel | |
Krill Omega-3 | Nature Made | 1.00 softgel | |
Cellular Renewal | Nature's Bounty | 1.00 softgel | |
Orthomega 820 | Orthomega | 1.00 softgel | |
Cardio Support | Bluebonnet Nutrition | 1.00 softgel | |
Omega 3-6-9 1000 mg Softgels | NOW Foods | 1.00 softgel | |
Evening Primrose Oil Omega-6 | Nature's Wellness | 1.00 softgel | |
Skin & Heart Omega-9 | Epax | 1.00 softgel | |
Wheat Germ Oil with Omega-3 | Garden of Life | 1.00 softgel | |
Orthomega 820 Capsules | Orthomega | 1.00 softgel | |
EPO Liquid | BodyBio | 0.50 teaspoon | |
Omega-3 Liquid Fish Oil | Nordic Naturals | 1.00 teaspoon | |
Women's Balance | NOW Foods | 2.00 softgels | |
Premium DHA | Deal Supplement | 2.00 softgels | |
Omega-3 Fish Oil Softgels | Dr. Tobias | 2.00 softgels | |
Krill Oil Omega-3 | MegaRed | 2.00 softgels | |
Safflower Oil & Evening Primrose Blend | Herbal Vitality | 2.00 softgels | |
Ultimate Omega 2X | Nordic Naturals | 2.00 softgels | |
Omega-3 Softgel Capsules | Momentous | 2.00 softgels | |
Omega-3 Fish Oil | Dr. Tobias | 2.00 softgels | |
Triple Strength Fish Oil | WOW Life Science | 1.00 soft gel | |
Omega-3 Fish Oil | Nature Made | 1.00 soft gel | |
Ultra Omega-3 Fish Oils | NOW Foods | 1.00 soft gel | |
Maximum Omega 2000 | Carlson | 1.00 soft gel | |
Sea Buckthorn & Omega Blend | Connoils By Kraft | 1.00 soft gel |
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