EPA (Omega-3)

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About EPA (Omega-3)

Docosahexaenoic Acid (DHA)

Overview

Docosahexaenoic acid (DHA) is a long-chain omega-3 fatty acid that plays a crucial role in the development and functioning of the human body, particularly in the brain and eyes[1][2]. It is primarily found in fish oil and is known for its anti-inflammatory, neuroprotective, and cardiovascular benefits[2]. Historically, DHA has been part of traditional diets rich in fish, such as the Mediterranean diet, which is associated with healthier hearts[1].

Forms and Variations

DHA supplements are available in various forms, including fish oil capsules, algal oil (for vegetarians and vegans), and fortified foods like infant formula[4]. The choice of form often depends on dietary preferences and the need for vegetarian or vegan options. Algal oil is a popular alternative for those who do not consume fish products[4].

Dosage and Administration

The recommended daily intake of DHA varies, but general guidelines suggest 200–500 mg combined with eicosapentaenoic acid (EPA) for overall health[3]. DHA supplements are typically taken once or twice daily with meals to enhance absorption and reduce gastrointestinal side effects[4].

Scientific Research and Mechanism of Action

DHA works by incorporating into cell membranes, influencing membrane fluidity, and interacting with cell signaling pathways to exert its anti-inflammatory effects[2]. It reduces inflammation by decreasing pro-inflammatory cytokines and inhibiting the NF-κB signaling pathway[2]. Research highlights DHA"s role in improving heart health, cognitive function, and eye health[1][3].

Benefits and Potential Uses

DHA has been linked to several health benefits, including reducing the risk of heart disease, improving ADHD symptoms, and supporting fetal brain development during pregnancy[1][3]. It may also help reduce inflammation in conditions like rheumatoid arthritis and potentially lower the risk of certain cancers[3].

Side Effects and Risks

Common side effects of DHA supplements include gastrointestinal issues such as bloating and fishy aftertaste[4]. While generally safe, high doses may increase the risk of bleeding due to its anticoagulant effects[4].

Interactions and Precautions

DHA may interact with anticoagulant medications, increasing the risk of bleeding[4]. Pregnant women and individuals with bleeding disorders should consult a healthcare provider before taking DHA supplements[4].

Impact on Biomarkers

DHA supplementation can increase the omega-3 index in blood, a marker associated with reduced heart disease risk[3]. It may also improve cholesterol profiles by decreasing triglycerides and increasing HDL cholesterol[3].

Overdose and Toxicity

While DHA is generally safe, excessive intake may lead to gastrointestinal side effects and increased bleeding risk[4]. The safe upper limit for DHA intake is not well-defined, but doses above 3 grams per day are typically not recommended without medical supervision[4].

Disclaimer

The information provided in this document is for educational purposes only and does not constitute medical advice. It is essential to consult with a qualified healthcare professional for any health concerns or before making any decisions related to your health or treatment.

Products

Name Brand Serving Size Ingredients
Ultimate Omega Nordic Naturals 2.00 Capsule/Tablet
Omega Match Ahiflower Oil Supplement Purina 30.00 ml
Algae DHA Corbion 1.00 capsule
DHEA 25mg Capsules Ortho Molecular Products 1.00 capsule
DHEA Supplement 25mg BrainMD 1.00 capsule
Pure EPO Pure Encapsulations 1.00 capsule
Organic Flaxseed Oil Capsules NOW Foods 1.00 capsule
EyePro Bausch + Lomb 1.00 capsule
Superba Krill Oil Aker BioMarine 1.00 capsule
Antarctic Krill Oil Transparent Labs 1.00 capsule
Krill-plex Pure Encapsulations 1.00 capsule
SuperiorRed Krill Oil NatureMyst 1.00 capsule
Omega Balance Garden of Life 1.00 capsule
Vegan Omega Complex Vega 1.00 capsule
EicosaCaps Omega 3 & 6 S Dechra 1.00 capsule
Omega Balance Therascience 1.00 capsule
EPO Plus GNC 2.00 capsules
Plant-Based Omega-3 Vegan Essentials 2.00 capsules
Plant-Based Omega 3-6-9 MegaFood 2.00 capsules
DHA Brain Support Nordic Naturals 1.00 softgel
HeartGuard with Aged Garlic and Omega-3 GNC 1.00 softgel
Aloe Vera & Omega-3 Skin Support Solgar 1.00 softgel
Astaxanthin Plus Omega-3 Pure Encapsulations 1.00 softgel
Coconut Oil and Omega-3 Blend Optimum Nutrition 1.00 softgel
CoQ10 Plus Omega-3 Garden of Life 1.00 softgel
DHA Omega-3 KD Nutra 1.00 softgel
DHA Focus Nature's Bounty 1.00 softgel
Evening Primrose Oil Softgels Nature's Bounty 1.00 softgel
Omega-3 Flaxseed Oil GNC 1.00 softgel
Flaxseed Oil with Lignans Barlean's 1.00 softgel
Vegan Omega-3 Blend Nature's Bounty 1.00 softgel
Heart Health Formula Optimum Nutrition 1.00 softgel
Omega Balance NOW Foods 1.00 softgel
Krill Omega-3 Nature Made 1.00 softgel
Cellular Renewal Nature's Bounty 1.00 softgel
Orthomega 820 Orthomega 1.00 softgel
Cardio Support Bluebonnet Nutrition 1.00 softgel
Omega 3-6-9 1000 mg Softgels NOW Foods 1.00 softgel
Evening Primrose Oil Omega-6 Nature's Wellness 1.00 softgel
Skin & Heart Omega-9 Epax 1.00 softgel
Wheat Germ Oil with Omega-3 Garden of Life 1.00 softgel
Orthomega 820 Capsules Orthomega 1.00 softgel
EPO Liquid BodyBio 0.50 teaspoon
Omega-3 Liquid Fish Oil Nordic Naturals 1.00 teaspoon
Women's Balance NOW Foods 2.00 softgels
Premium DHA Deal Supplement 2.00 softgels
Omega-3 Fish Oil Softgels Dr. Tobias 2.00 softgels
Krill Oil Omega-3 MegaRed 2.00 softgels
Safflower Oil & Evening Primrose Blend Herbal Vitality 2.00 softgels
Ultimate Omega 2X Nordic Naturals 2.00 softgels
Omega-3 Softgel Capsules Momentous 2.00 softgels
Omega-3 Fish Oil Dr. Tobias 2.00 softgels
Triple Strength Fish Oil WOW Life Science 1.00 soft gel
Omega-3 Fish Oil Nature Made 1.00 soft gel
Ultra Omega-3 Fish Oils NOW Foods 1.00 soft gel
Maximum Omega 2000 Carlson 1.00 soft gel
Sea Buckthorn & Omega Blend Connoils By Kraft 1.00 soft gel
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