Astragalus

Overview

Astragalus is a perennial plant native to China, Mongolia, and Korea, with over 2,000 species, though only a few are used medicinally^[1][2]. It is traditionally used in Chinese medicine to strengthen the body against disease and is classified as an adaptogen, believed to help the body respond to stress^[2][3]. Astragalus root is used to make medicine and is often combined with other herbs to enhance its effects^[1][4].

Forms and Variations

Astragalus is available in various forms, including liquid extracts, capsules, powders, and teas^[2]. The most commonly used species for supplements are Astragalus membranaceus and Astragalus mongholicus^[2]. Some species, like Astragalus lentiginosus, contain toxins and are not used in human supplements^[1][3].

Dosage and Administration

The dosage of astragalus varies widely depending on the condition being treated. Typically, it is taken orally in doses ranging from 500 mg to 5 grams per day, often divided into multiple doses^[1]. For optimal absorption, it should be taken with meals to minimize gastrointestinal side effects. Astragalus can also be administered intravenously for certain conditions like heart failure and cancer treatment side effects^[1].

Scientific Research and Mechanism of Action

Astragalus is believed to work by stimulating the immune system and reducing inflammation^[1][3]. It contains antioxidants that may help protect cells from damage^[2]. Research suggests potential benefits in improving heart function, reducing chemotherapy side effects, and enhancing immune response in cancer patients^[4]. However, more rigorous studies are needed to confirm these effects^[3].

Benefits and Potential Uses

Astragalus is used for a variety of health conditions, including boosting the immune system, preventing colds, lowering blood pressure, and treating diabetes^[1][4]. It may also help with heart disease, kidney disease, and as a general tonic to improve overall health^[4][5]. Additionally, astragalus has been used to enhance athletic performance and improve wound healing^[1].

Side Effects and Risks

Astragalus is generally considered safe at low to moderate doses, with few side effects reported^[4]. However, it may interact with certain medications or exacerbate autoimmune conditions^[4]. Some species of astragalus contain toxins, but these are not typically found in dietary supplements^[1][3].

Interactions and Precautions

Astragalus may interact with blood thinners, diabetes medications, and immunosuppressants^[4]. It should be used cautiously in individuals with autoimmune diseases or those undergoing surgery due to its potential effects on blood clotting and immune response^[4]. Pregnant or breastfeeding women should consult a healthcare provider before use^[5].

Impact on Biomarkers

Astragalus may influence biomarkers related to immune function, such as white blood cell count, and could potentially affect blood sugar levels in diabetic patients^[4][5]. However, specific studies on its impact on common biomarkers are limited.

Overdose and Toxicity

There is limited information on the risks of astragalus overdose. However, high doses may increase the risk of interactions with other medications or exacerbate underlying health conditions^[4]. Symptoms of toxicity are not well-documented, but caution should be exercised when exceeding recommended dosages.

Disclaimer

The information provided in this document is for educational purposes only and does not constitute medical advice. It is essential to consult with a qualified healthcare professional for any health concerns or before making any decisions related to your health or treatment.