Aged Garlic Extract

Overview

Aged Garlic Extract (AGE) is a dietary supplement derived from garlic that has been aged for several months. This process transforms the harsh, unstable compounds found in raw garlic into stable, bioavailable compounds with potential health benefits^[1]. Historically, garlic has been used for its medicinal properties, but AGE offers a more palatable and effective alternative, as it lacks the strong odor and taste of raw garlic^[2]. AGE is primarily used for its antioxidant, anti-inflammatory, and cardiovascular health benefits^[2].

Forms and Variations

Aged Garlic Extract is commonly available in capsule or tablet form. The most well-known brand, Kyolic AGE, is produced by soaking sliced garlic in an aqueous ethanol solution for up to 20 months^[3]. Variations may include different formulations with additional ingredients, but the core process involves aging garlic to enhance its bioactive compounds. The choice of form often depends on personal preference and the specific health benefits sought^[2].

Dosage and Administration

The typical dosage of Aged Garlic Extract varies, but common recommendations range from 600 to 1,200 mg per day, taken once or twice daily^[2]. It is advisable to follow the manufacturer"s instructions and consult with a healthcare provider for personalized guidance. AGE can be taken with meals to minimize potential gastrointestinal side effects^[2].

Scientific Research and Mechanism of Action

Research on AGE has shown its potential in reducing cardiovascular risk factors, such as lowering low attenuation plaque in coronary arteries^[3]. The aging process converts allicin and other unstable compounds into more stable forms like S-allylcysteine (SAC), which contribute to its antioxidant and anti-inflammatory effects^[1]. Studies suggest that AGE may enhance cardiovascular health by improving lipid profiles and reducing inflammation^[2].

Benefits and Potential Uses

Aged Garlic Extract is associated with several health benefits, including cardiovascular protection, antioxidant activity, and potential anti-cancer properties^[1]. It may also support immune function and reduce the risk of certain infections^[2]. AGE is rich in vitamins and minerals like manganese, vitamin B6, and selenium, contributing to its nutritional value^[2].

Side Effects and Risks

Generally, Aged Garlic Extract is well-tolerated, but it may cause mild gastrointestinal side effects such as bloating or gas in some individuals^[2]. Due to its potential effects on blood clotting, individuals with bleeding disorders or those taking anticoagulant medications should use AGE with caution^[2].

Interactions and Precautions

Aged Garlic Extract may interact with blood thinners and diabetes medications, so it is crucial to consult with a healthcare provider before use, especially for individuals with these conditions^[2]. Pregnant or breastfeeding women should also exercise caution and consult a healthcare professional before using AGE^[2].

Impact on Biomarkers

AGE may influence biomarkers related to cardiovascular health, such as lipid profiles and inflammatory markers. It can help reduce low-density lipoprotein (LDL) cholesterol and triglycerides while increasing high-density lipoprotein (HDL) cholesterol^[3].

Overdose and Toxicity

There is limited information on the toxicity of Aged Garlic Extract, but high doses may exacerbate gastrointestinal side effects. It is essential to follow recommended dosages and consult with a healthcare provider if concerns arise^[2].

Disclaimer

The information provided in this document is for educational purposes only and does not constitute medical advice. It is essential to consult with a qualified healthcare professional for any health concerns or before making any decisions related to your health or treatment.